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there was a 32% reduction in the number of patients inappropriately receiving B-12 (521 to 352) , and the proportion of patients receiving B-12 at the correct frequency rose from 58% to 72%

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MYCN abundance modestly influenced sensitivity: MYCN downregulation in IMR-5/75 cells slightly reduced toxicity, while MYCN induction in SH-SY5Y/MYCN slightly increased it, though neither change reached significance

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